Schoenberg M H, Büchler M, Beger H G
Department of General Surgery, University of Ulm, Germany.
Hepatogastroenterology. 1994 Aug;41(4):313-9.
Oxygen free radicals mediate an important step in the initiation of experimental acute pancreatitis. These reactive oxygen metabolites are generated at an early stage of the disease. However, the source of the enhanced production of oxygen radicals still remains unclear. Experimentally, the effectiveness of scavenger treatment varied from one model to another, the differences depending on the experimental model and not on the form of pancreatitis that was induced. In most studies the experimental animals were pretreated before inducing acute pancreatitis. This does not mirror clinical reality, since patients are admitted to the hospital after the onset of the disease. It was shown in cerulein-induced pancreatitis, however, that scavenger treatment also mitigated the pancreatic tissue damage after induction of acute pancreatitis. Moreover, antioxidant treatment also attenuated the extrapancreatic complications, thus improving the final outcome of the disease. Initial indirect observations also suggest that in human acute recurrent and chronic pancreatitis oxygen free radicals are generated and add to the damage. Well-defined controlled clinical trials involving patients suffering from acute pancreatitis are therefore needed to validate the role of oxygen radicals in this disease.
氧自由基在实验性急性胰腺炎的起始过程中介导了重要步骤。这些活性氧代谢产物在疾病早期产生。然而，氧自由基产生增加的来源仍不清楚。在实验中，清除剂治疗的效果因模型而异，差异取决于实验模型而非诱导的胰腺炎形式。在大多数研究中，实验动物在诱导急性胰腺炎之前进行了预处理。这并不反映临床实际情况，因为患者在疾病发作后才入院。然而，在雨蛙肽诱导的胰腺炎中发现，清除剂治疗在急性胰腺炎诱导后也减轻了胰腺组织损伤。此外，抗氧化治疗还减轻了胰腺外并发症，从而改善了疾病的最终结局。初步的间接观察还表明，在人类急性复发性胰腺炎和慢性胰腺炎中会产生氧自由基并加重损伤。因此，需要开展涉及急性胰腺炎患者的明确对照临床试验，以验证氧自由基在该疾病中的作用。
