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老年大鼠十二指肠血管和肥大细胞延迟性辐射诱导反应的改变

Modification of delayed radiation-induced reactions of duodenal vessels and mast cells in old rats.

作者信息

Popuchiev V V, Mikhina L N, Yakovleva N D, Konoplyannikov A G, Yuzhakov V V, Odintsova E A, Brodskii R A, Sevan'kaeva L E, Kita K, Kita I

机构信息

Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk; Institute of Industrial Organic Chemistry, Pschina, Poland.

出版信息

Bull Exp Biol Med. 2003 Oct;136(4):399-403. doi: 10.1023/b:bebm.0000010963.25058.a3.

DOI:10.1023/b:bebm.0000010963.25058.a3
PMID:14714094
Abstract

Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body gamma-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.

摘要

在接受单次全身7.5 Gy剂量的γ射线照射1年后,Wistar大鼠十二指肠固有层的血管和肥大细胞出现了明显的超微结构变化。用甲吡酮抑制肾上腺皮质功能可减轻结构损伤并提高动物存活率。

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