肾上腺皮质功能抑制条件下γ射线照射后松果体的超微结构
Ultrastructure of the pineal gland after gamma-irradiation under conditions of inhibition of adrenocortical function.
作者信息
Popuchiev V V, Yakovleva N D, Konoplyannikov A G, Kvetnoi I M, Kita K, Kita I
机构信息
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk.
出版信息
Bull Exp Biol Med. 2003 Jun;135(6):603-7. doi: 10.1023/a:1025402007545.
PMID:12937686
Abstract
Electron microscopy showed that whole-body gamma-irradiation in sublethal doses led to the appearance of injuries in pinealocytes, glial cells, and vessels of the pineal gland in rats. Limitation of the nonspecific effect of gamma-irradiation via inhibition of adrenocortical function with metopirone in physiological doses reduced the radiation-induced ultrastructural damage to the pineal gland.
摘要
电子显微镜检查显示，亚致死剂量的全身γ射线照射导致大鼠松果体细胞、神经胶质细胞和松果体血管出现损伤。通过生理剂量的美替拉酮抑制肾上腺皮质功能来限制γ射线照射的非特异性效应，可减少辐射诱导的松果体超微结构损伤。
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