Soyka M, Preuss U W, Koller G, Zill P, Bondy B
Psychiatric Hospital, University of Munich, Germany.
J Neural Transm (Vienna). 2004 Jan;111(1):101-9. doi: 10.1007/s00702-003-0064-0. Epub 2003 Dec 3.
The 5-HT1B receptor gene has been postulated to play a modulatory role in alcohol consumption and alcohol dependence, and was considered a candidate gene for alcoholism. More recently, the association of the 5-HT receptor gene polymorphism and antisocial personality traits in alcoholism has been discussed. This possible association was studied using material from our gene bank for alcoholism. The research instruments used to phenotype patients were partly adopted from the US Collaborative Study on the Genetics of Alcoholism (COGA) which include anxiety- and depression-related scales from personality inventories such as the temperament and character inventory (TCI), the NEO-Five-Factor Inventory (NEO-FFI) and the Minnesota Multiphase Personality Inventory (MMPI-2). Based on the examination of 164 alcoholic subjects, an association was found between a lower frequency of the 5-HT 1B 861C allele, antisocial personality traits and conduct disorder in alcohol-dependent subjects. Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed.
5-HT1B受体基因被认为在酒精摄入和酒精依赖中起调节作用，曾被视为酒精中毒的候选基因。最近，人们讨论了5-HT受体基因多态性与酒精中毒患者反社会人格特质之间的关联。我们利用酒精中毒基因库中的材料对这种可能的关联进行了研究。用于对患者进行表型分析的研究工具部分采用了美国酒精中毒遗传学合作研究（COGA）的工具，其中包括来自人格量表（如气质与性格量表（TCI）、NEO五因素量表（NEO-FFI）和明尼苏达多相人格量表（MMPI-2））中与焦虑和抑郁相关的量表。通过对164名酒精依赖受试者的检测，发现酒精依赖受试者中5-HT 1B 861C等位基因频率较低与反社会人格特质及品行障碍之间存在关联。成人反社会人格在男性中比在女性中更为常见。本文讨论了这些发现可能的意义。
