重症肌无力患者的血清抗肌联蛋白抗体
[Serum anti-titin antibody in patients with myasthenia gravis].
作者信息
Li Yan-feng, Zhang Jun-bao, Cui Li-ying
机构信息
Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Dec;25(6):725-7.
OBJECTIVE
To study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis (MG) with thymoma.
METHOD
The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups.
RESULTS
The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma.
CONCLUSION
Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.
目的
研究血清抗肌联蛋白抗体水平在伴胸腺瘤重症肌无力（MG）诊断中的临床意义。
方法
采用ELISA法分析40例健康对照组、90例MG患者、17例伴胸腺瘤MG患者及7例非MG胸腺瘤患者的血清抗肌联蛋白抗体，比较各组阳性率。
结果
伴胸腺瘤MG患者抗肌联蛋白抗体阳性率显著高于MG患者（94%和3%，P<0.01）。根据Osserman分型，抗肌联蛋白抗体主要存在于Ⅳ期患者中（43%），7例非MG胸腺瘤患者中也有2例存在该抗体。
结论
血清抗肌联蛋白抗体检测有助于伴胸腺瘤MG的诊断。
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