Zhou Jian-hua, Huang Ai-xia, Liu Tong-lin
Department of Pediatrics, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 May;24(5):418-21.
To study the effect of Colquhounia root tablet (CRT) in treating childhood Henoch-Schonlein purpura nephritis (HSPN) and compared with tripterygium wilfordii multiglycoside tablet (TWMGT).
Eighty-two children with HSPN were divided into the CRT group and the control group. To patients of nephritic type, treatment with CRT and TWMGT was applied separately, but to those of nephrotic type, the treatment was given together with prednisone. Therapeutic effect and changes of related indexes, including urinary protein, retinal-binding protein (RBP), N-acetyl-beta-glucosaminidase (NAG), were observed after patients received treatment for 6 months.
The complete remission (CR) rate and partial remission (PR) rate in patients of nephritic type in the treated group was 58.8% and 41.2% respectively, while those in the control group was 20.8% and 66.7% respectively, and the ineffective rate being 12.5%. Comparison of the therapeutic effect between the two groups showed significant difference (P < 0.05). Although the CR rate in patients of nephrotic type in the treated group was higher than that in the control group, the difference was insignificant (P > 0.05). The urinary levels of protein, RBP and NAG lowered in both groups, but level of urinary protein in the treated group of nephritic type after 6 months of treatment was significantly lower than that in the control group (P < 0.05).
CRT shows obvious effect in improving childhood HSPN of nephritic type, nephrotic type and attenuating the tubulointerstitial lesions, compared with TWMGT, CRT is more effective in lowering proteinuria and better in total effective rate.
研究火把花根片（CRT）治疗小儿紫癜性肾炎（HSPN）的疗效，并与雷公藤多苷片（TWMGT）进行比较。
将82例HSPN患儿分为CRT组和对照组。对肾炎型患者分别给予CRT和TWMGT治疗，对肾病型患者则联合泼尼松治疗。观察患者治疗6个月后的疗效及尿蛋白、视黄醇结合蛋白（RBP）、N-乙酰-β-葡萄糖苷酶（NAG）等相关指标的变化。
治疗组肾炎型患者的完全缓解（CR）率和部分缓解（PR）率分别为58.8%和41.2%，对照组分别为20.8%和66.7%，无效 率为12.5%。两组疗效比较差异有统计学意义（P<0.05）。治疗组肾病型患者的CR率虽高于对照组，但差异无统计学意义（P>0.05）。两组尿蛋白、RBP及NAG水平均降低，但治疗组肾炎型患者治疗6个月后的尿蛋白水平明显低于对照组（P<0.05）。
CRT对小儿肾炎型、肾病型HSPN均有明显疗效，能减轻肾小管间质病变，与TWMGT比较，CRT降低蛋白尿效果更显著，总有效率更高。
