Ni Yongbin, Wang Hongyu, Hu Dayi, Zhang Weizhong
Department of Cardiology, People's Hospital, Peking University, Beijing 100044, PR China.
Hypertens Res. 2003 Nov;26(11):871-4. doi: 10.1291/hypres.26.871.
Aortic pulse wave velocity (PWV) is a significant and independent predictor of cardiovascular disease in hypertensive subjects and in patients with end-stage renal disease, but there have been few studies on PWV in Chinese patients with essential hypertension. In this cross-sectional study, we investigated 3,156 consecutive patients (mean age: 53.7 +/- 11.58 years) of the Hypertension Division of Ruijin Hospital in Shanghai. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured using a validated automatic device. PWV in patients with pulse pressure (PP) > or = 60 mmHg was significantly greater than that in patients with PP < 60 mmHg (p < 0.01). PP and PWV were positively related to age (PP: r = 0.396, p = 0.001; PWV: r = 0.531, p = 0.001). After adjustment by age and heart rate, PWV was still closely related to PP (r = 0.249, p = 0.001). At any given systolic blood pressure (SBP), PWV significantly decreased with the increase of diastolic blood pressure (DBP), whereas at any given DBP there was a significant increase of PWV with the increase of SBP. In conclusion, PWV was the major determinant of PP, and was highest in Chinese patients with isolated systolic hypertension, followed by those with systolic and diastolic hypertension, isolated diastolic hypertension, and normal blood pressure.
主动脉脉搏波速度（PWV）是高血压患者和终末期肾病患者心血管疾病的重要且独立的预测指标，但针对中国原发性高血压患者的PWV研究较少。在这项横断面研究中，我们调查了上海瑞金医院高血压科连续收治的3156例患者（平均年龄：53.7±11.58岁）。除了用血压计测量血压外，还使用经过验证的自动设备测量主动脉PWV。脉压（PP）≥60 mmHg的患者的PWV显著高于PP＜60 mmHg的患者（p＜0.01）。PP和PWV与年龄呈正相关（PP：r = 0.396，p = 0.001；PWV：r = 0.531，p = 0.001）。在对年龄和心率进行校正后，PWV仍与PP密切相关（r = 0.249，p = 0.001）。在任何给定的收缩压（SBP）下，PWV随舒张压（DBP）的升高而显著降低，而在任何给定的DBP下，PWV随SBP的升高而显著升高。总之，PWV是PP的主要决定因素，在单纯收缩期高血压的中国患者中最高，其次是收缩期和舒张期高血压患者、单纯舒张期高血压患者和血压正常者。
