Pitasawat Benjawan, Choochote Wej, Tuetun Benjawan, Tippawangkosol Pongsri, Kanjanapothi Duangta, Jitpakdi Atchariya, Riyong Duangrat
Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
J Vector Ecol. 2003 Dec;28(2):234-40.
Three Curcuma species, Curcuma aeruginosa (pink and blue ginger), Cu. aromatica (aromatic turmeric), and Cu. xanthorrhiza (giant curcuma), were selected for investigation of mosquito repellent activity. In a laboratory study, a 95% ethanol extract of each plant was tested for repellent activity of Aedes togoi on human volunteers. Only Cu. aromatica extract showed repellency against Ae. togoi with ED50 and ED95 values of 0.061 and 1.55 mg/cm2, respectively. It also provided biting protection for 3.5 h when applied at a concentration of 25 g%. The ethanolic extract of Cu. aromatica was therefore chosen for further repellent activity under field conditions, where it had a protective effect against Armigeres subalbatus, Culex quinquefasciatus, and Cx. tritaeniorhynchus. The ethanol-extracted Cu. aromatica did not cause dermal irritation when applied to human skin. No adverse effects on human volunteers were observed 2 mo after application. Therefore, Cu. aromatica extract can be applied as an effective personal protection measure against mosquito bites.
选取了三种姜黄属植物，即莪术（粉蓝姜）、郁金（温郁金）和姜黄（大莪术），用于研究其驱蚊活性。在一项实验室研究中，对每种植物的95%乙醇提取物进行了测试，以检测其对人类志愿者身上的东乡伊蚊的驱避活性。只有郁金提取物对东乡伊蚊表现出驱避作用，其半数有效剂量（ED50）和95%有效剂量（ED95）分别为0.061和1.55毫克/平方厘米。当以25%的浓度施用时，它还能提供3.5小时的防叮咬保护。因此，郁金的乙醇提取物被选用于进一步研究其在野外条件下的驱避活性，在野外它对骚扰阿蚊、致倦库蚊和三带喙库蚊具有保护作用。将乙醇提取的郁金应用于人体皮肤时不会引起皮肤刺激。施用2个月后，未观察到对人类志愿者有任何不良影响。因此，郁金提取物可作为一种有效的个人防蚊措施。
