Atabek M Emre, Pirgon Ozgur, Erkul Ibrahim
Department of Pediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey.
J Pediatr Endocrinol Metab. 2003 Dec;16(9):1245-8. doi: 10.1515/jpem.2003.16.9.1245.
Hyperhomocysteinemia is a risk factor for premature atherosclerotic vascular disease and venous thrombosis. The aim of the present study was to assess plasma total homocysteine (tHCys) concentrations in adolescent patients with subclinical hypothyroidism.
Nineteen patients with subclinical hypothyroidism and 19 healthy children were studied. Fasting plasma concentrations of tHCys and its putative determinants (plasma concentrations of free thyroxine [FT4], folate, vitamin B12 and renal function) were measured.
tHCys concentrations showed no statistical difference between patients and controls (p > 0.05). Moreover, the difference in tHCys and total cholesterol concentrations was not significant between patients with mild TSH elevations (< or = 10 mIU/l) and patients with prominent TSH elevations (> 10 mIU/l). No correlation was found between tHCys concentrations and its putative determinants.
We concluded that plasma tHCys concentrations were not increased in adolescent patients with subclinical hypothyroidism.
高同型半胱氨酸血症是早发性动脉粥样硬化性血管疾病和静脉血栓形成的危险因素。本研究的目的是评估亚临床甲状腺功能减退青少年患者的血浆总同型半胱氨酸（tHCys）浓度。
对19例亚临床甲状腺功能减退患者和19名健康儿童进行了研究。测量了空腹血浆tHCys浓度及其假定的决定因素（游离甲状腺素[FT4]血浆浓度、叶酸、维生素B12和肾功能）。
患者与对照组之间的tHCys浓度无统计学差异（p>0.05）。此外，轻度促甲状腺激素（TSH）升高（≤10 mIU/l）的患者与显著TSH升高（>10 mIU/l）的患者之间，tHCys与总胆固醇浓度的差异不显著。未发现tHCys浓度与其假定的决定因素之间存在相关性。
我们得出结论，亚临床甲状腺功能减退青少年患者的血浆tHCys浓度没有升高。
