Zhou Yande, Chen Yufang, Cao Xueqin, Liu Chunfeng, Xie Ying
Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
Department of Neurology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China ; Institute of Neuroscience, Soochow University Suzhou 215123, China.
Int J Clin Exp Med. 2014 Nov 15;7(11):4544-53. eCollection 2014.
To figure out plasma homocysteine (Hcy) status in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) compared with healthy subjects, and the effect of levothyroxine (L-T4) on plasma homocysteine status in patients with hypothyroidism.
PubMed Web of Science, and The Cochrane Library were used to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software.
Our meta-analysis indicated that plasma Hcy concentrations elevated in OH patients without L-T4 treatment compared with healthy subjects. However, this elevation was not observed in the comparison between patients withSH without L-T4 treatment and healthy subjects. Moreover, plasma Hcy levels were found to be higher in patients with OH without L-T4 treatment than in patients with SH without L-T4 treatment. Finally, plasma Hcy concentrations decreased after L-T4 treatment in patients with SH or OH.
Plasma Hcy status is associated with the severity of hypothyroidism and L-T4 treatment is helpful for patients with hypothyroidism to reduce the plasma Hcy levels.
与健康受试者相比，明确亚临床甲状腺功能减退症（SH）和临床甲状腺功能减退症（OH）患者的血浆同型半胱氨酸（Hcy）水平，以及左甲状腺素（L-T4）对甲状腺功能减退症患者血浆同型半胱氨酸水平的影响。
使用PubMed、科学网和考克兰图书馆来识别符合条件的研究。采用纽卡斯尔-渥太华质量评估量表来评估所选研究的质量。所有分析均使用STATA 12版软件进行。
我们的荟萃分析表明，未接受L-T4治疗的OH患者与健康受试者相比，血浆Hcy浓度升高。然而，在未接受L-T4治疗的SH患者与健康受试者的比较中未观察到这种升高。此外，发现未接受L-T4治疗的OH患者的血浆Hcy水平高于未接受L-T4治疗的SH患者。最后，SH或OH患者在接受L-T4治疗后血浆Hcy浓度降低。
血浆Hcy水平与甲状腺功能减退症的严重程度相关，L-T4治疗有助于甲状腺功能减退症患者降低血浆Hcy水平。
