Ordi Jaume, Creus Montserrat, Casamitjana Roser, Cardesa Antonio, Vanrell Juan A, Balasch Juan
Department of Pathology, Faculty of Medicine--University of Barcelona, Hospital Clínic--Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
J Assist Reprod Genet. 2003 Nov;20(11):465-73. doi: 10.1023/b:jarg.0000006709.61216.6f.
To investigate endometrial receptivity in terms of pinopode formation and alphavbeta3 integrin expression in infertile women with endometriosis during natural cycles.
We investigated the expression of alphavbeta3 integrin and pinopode formation in the endometrium of 12 infertile patients with stage I or II endometriosis as the only cause of infertility, 12 infertile patients having unexplained infertility, and 12 fertile women who were undergoing tubal sterilization. Two endometrial biopsies (postovulatory day +7 to +8 and 4 days later) were performed during a single menstrual cycle in each subject.
No statistically significant difference regarding alphavbeta3 integrin expression and pinopode formation was found between infertile patients with endometriosis and the two control groups.
alphavbeta3 integrin expression and pinopode formation are not reduced during the window of implantation in patients with stage I-II endometriosis. Whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with those markers of implantation, warrants further studies.
研究自然周期中子宫内膜异位症不孕女性的窗孔形成及αvβ3整合素表达情况，以此探讨子宫内膜容受性。
我们研究了12例因I期或II期子宫内膜异位症作为唯一不孕原因的不孕患者、12例不明原因不孕的不孕患者以及12例正在接受输卵管绝育术的有生育能力女性的子宫内膜中αvβ3整合素的表达及窗孔形成情况。在每个受试者的单个月经周期内进行两次子宫内膜活检（排卵后第7至8天及4天后）。
子宫内膜异位症不孕患者与两个对照组在αvβ3整合素表达及窗孔形成方面未发现统计学上的显著差异。
I-II期子宫内膜异位症患者在着床窗期αvβ3整合素表达及窗孔形成并未降低。这些结果是否意味着此类患者的子宫内膜容受性正常，或者是否增加了使用这些着床标志物评估子宫内膜临床价值的不确定性，有待进一步研究。
