短节段巴雷特食管的免疫组化黏蛋白表达

Immunohistochemical mucin expression of short-segment Barrett's esophagus.

作者信息

Yamamoto Soichiro, Kijima Hiroshi, Hara Tadashi, Kenmochi Takahiro, Kise Yoshifumi, Tanaka Hikaru, Chino Osamu, Shimada Hideo, Tanaka Makiko, Inokuchi Sadaki, Makuuchi Hiroyasu

机构信息

Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

出版信息

Tokai J Exp Clin Med. 2003 Jul;28(2):57-63.

PMID:14714830

Abstract

Barrett's mucosa consists of metaplastic columnar epithelium (specialized columnar epithelium) of the esophagus. Recently, "short-segment Barrett's esophagus (SSBE)" was proposed. In the present study, we examined immunohistochemical mucin expression and the Ki-67 labeling index (LI) of SSBE, in 5-15 mm lengths. All 27 SSBE cases showed gastric mucin (MUC5AC, HGM, MUC6). CD10 and MUC2, which were markers of intestinal phenotypes, were detected in 13 (48.1%) and 14 (51.9%) of the 27 SSBE cases. Ki-67 LI of SSBE positive cases for CD10 was 23.6 %, while that of SSBE negative cases for CD10 was 14.4 % (p < 0.05). SSBE cases were divided into two groups: one was gastric epithelium type with low Ki-67 LI, and the other was metaplastic epithelium with intestinal metaplasia and high Ki-67 LI. The latter group was suggested to be more important as a premalignant lesion of esophageal adenocarcinoma.

摘要

巴雷特黏膜由食管的化生柱状上皮（特殊柱状上皮）组成。最近，有人提出了“短节段巴雷特食管（SSBE）”。在本研究中，我们检查了长度为5 - 15毫米的SSBE的免疫组化粘蛋白表达和Ki-67标记指数（LI）。所有27例SSBE病例均显示胃粘蛋白（MUC5AC、HGM、MUC6）。在27例SSBE病例中，分别有13例（48.1%）和14例（51.9%）检测到作为肠表型标志物的CD10和MUC2。CD10阳性的SSBE病例的Ki-67 LI为23.6%，而CD10阴性的SSBE病例的Ki-67 LI为14.4%（p < 0.05）。SSBE病例分为两组：一组是Ki-67 LI较低的胃上皮类型，另一组是伴有肠化生且Ki-67 LI较高的化生上皮。后一组被认为作为食管腺癌的癌前病变更为重要。