Morrison John C, Chauhan Suneet P
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
Clin Perinatol. 2003 Dec;30(4):757-801. doi: 10.1016/s0095-5108(03)00112-x.
A comprehensive evidence-based review of the clinical data leads to the conclusion that if patients at high risk for preterm birth (eg, prior preterm birth because of preterm labor, twins and higher-order multiple gestation, women who have preterm labor during the current pregnancy tocolyzed effectively) use the comprehensive system of HUAM correctly (ie, daily nursing care and twice-daily monitoring) with appropriate alarm rates and sensitive monitors, the incidence of early diagnosis of preterm labor, effective prolongation of pregnancy with fewer preterm births, and a reduction in neonatal morbidity is always demonstrated when the study group is compared with a control group consisting of women receiving standard care available to obstetricians in the United States. The authors expect that there will always be arguments regarding whether the monitor or the nurse contributes most to preterm birth reduction. Even when the alerts of detected contractions or patient-reported symptoms are sounded, the issue of prompt and effective medical intervention will always be hotly debated. The appropriate research design that tests HUAM while allowing various diagnostic and treatment modalities that physicians employ around the United States must be individualized. Physicians must make the decision, based on the evidence, regarding whether or not this system would benefit their patients. While investigators argue about research designs and statistical analyses, physicians simply want the best outcomes for their patients, which is what women and the whole of society also want. Based on the available evidence, it is clear that when the comprehensive system of HUAM is used appropriately in the right patients, everyone benefits.
对临床数据进行全面的循证综述后得出的结论是,如果早产高危患者(例如,因早产临产而有早产史、双胞胎及多胎妊娠、当前妊娠期间早产临产且接受有效宫缩抑制治疗的女性)正确使用HUAM综合系统(即每日护理和每日两次监测),配备适当的警报率和灵敏的监测器,与由接受美国产科医生可提供的标准护理的女性组成的对照组相比,研究组总能显示出早产临产早期诊断的发生率、有效延长孕周且减少早产以及降低新生儿发病率的效果。作者预计,关于监测器或护士对减少早产的贡献最大这一问题总会存在争论。即使检测到宫缩或患者报告症状的警报响起,迅速有效的医疗干预问题也总会引发激烈辩论。在允许美国各地医生采用各种诊断和治疗方式的同时对HUAM进行测试的适当研究设计必须个体化。医生必须根据证据决定该系统是否会使他们的患者受益。虽然研究人员在争论研究设计和统计分析,但医生只希望为他们的患者带来最佳结果,而这也是女性和整个社会所希望的。基于现有证据,很明显,当在合适的患者中适当使用HUAM综合系统时,每个人都会受益。