Vidaeff Alex C, Doyle Nora M, Gilstrap Larry C
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School at Houston, The University of Texas Medical School at Houston, 6431 Fannin St., Suite 3.604 Houston, TX 77030, USA.
Clin Perinatol. 2003 Dec;30(4):825-40, vii. doi: 10.1016/s0095-5108(03)00102-7.
The available data unambiguously support the beneficial, short-term fetal effects of antenatal corticosteroids in women at risk for preterm delivery. There are still several incompletely addressed questions, including the use of corticosteroids in women with preterm premature rupture of membranes, the optimal corticosteroid preparation to be used, and the impact of repeated dosing. These issues are discussed in this review from the perspective of recent scientific evidence on the mechanisms responsible for positive short-term effects on survival and possible harmful long-term effects.
现有数据明确支持产前使用皮质类固醇对有早产风险的女性的胎儿具有短期有益作用。仍有几个未完全解决的问题，包括胎膜早破早产女性使用皮质类固醇的情况、最佳使用的皮质类固醇制剂以及重复给药的影响。本综述从关于对生存产生积极短期影响的机制及可能的有害长期影响的最新科学证据的角度对这些问题进行了讨论。
