Gewillig Marc, Boshoff Derize E, Dens Joseph, Mertens Luc, Benson Lee N
Paediatric Cardiology, University Hospitals, Leuven, Belgium.
J Am Coll Cardiol. 2004 Jan 7;43(1):107-12. doi: 10.1016/j.jacc.2003.08.029.
The goal of this study was to assess a new approach to stent the arterial duct in neonates with a duct-dependent pulmonary circulation.
Previous attempts to stent the neonatal arterial duct were unsatisfactory. Learning from these failures, we speculated that covering the complete length of the duct with current low-profile stents might avoid previous problems.
Ten neonates with duct-dependent pulmonary circulations through a short straight duct were treated with stent implantation. The duct was crossed with an atraumatic 0.014-inch wire. A low-profile premounted coronary stent (outer diameter <4F, length 13 to 24 mm, diameter 3.0 to 4.0 mm) was positioned within the duct, not protected by a sheath; care was taken to cover the complete length of the duct from the aortaductal junction until well within the pulmonary trunk.
All stents could safely be deployed with adequate pulmonary flow at early- and medium-term follow-up. There were no procedure-related complications; one patient died early from sepsis. All patients had adequate relief of cyanosis for at least three to four months. During follow-up, the pulmonary vasculature bed had grown without distortion. Acute occlusion of a stented duct was not observed. Ductal flow progressively decreased slowly over several months by luminal narrowing, until the stented duct had either become redundant or was dilated/restented or until elective staged surgery was performed.
With current technology, complete stenting of a short straight duct is a safe and effective palliation, allowing adequate growth of the pulmonary arteries.
本研究的目的是评估一种用于为依赖动脉导管的新生儿肺循环置入支架的新方法。
以往为新生儿动脉导管置入支架的尝试并不理想。从这些失败中吸取教训,我们推测用目前的低轮廓支架覆盖导管的全长可能会避免先前的问题。
对10例通过短直动脉导管依赖肺循环的新生儿进行支架植入治疗。用一根无创伤的0.014英寸导丝穿过导管。将一个低轮廓预装冠状动脉支架(外径<4F,长度13至24mm,直径3.0至4.0mm)放置在导管内,不使用鞘保护;小心地从主动脉导管连接处到肺动脉主干内部完全覆盖导管全长。
在早期和中期随访中,所有支架均能安全置入,肺血流充足。没有与手术相关的并发症;1例患者早期死于败血症。所有患者的紫绀至少缓解了三到四个月。随访期间,肺血管床正常生长,未出现扭曲。未观察到支架置入的导管急性闭塞。几个月内,导管血流因管腔狭窄而逐渐缓慢减少,直到置入支架的导管变得多余或扩张/再次置入支架,或直到进行择期分期手术。
采用目前的技术,对短直导管进行完全支架置入是一种安全有效的姑息治疗方法,可使肺动脉充分生长。