1型人类免疫缺陷病毒感染母亲所生未感染婴儿外周血白细胞上CXCR4和CCR5表达的年龄相关变化
Age-related changes in expression of CXCR4 and CCR5 on peripheral blood leukocytes from uninfected infants born to human immunodeficiency virus type 1-infected mothers.
作者信息
Shalekoff Sharon, Gray Glenda E, Tiemessen Caroline T
机构信息
AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, Johannesburg, South Africa.
出版信息
Clin Diagn Lab Immunol. 2004 Jan;11(1):229-34. doi: 10.1128/cdli.11.1.229-234.2004.
Abstract
Cross-sectional analysis of human immunodeficiency virus-exposed, uninfected infants revealed high proportions of CXCR4-expressing cells in their cord blood, which declined at 4.5 months and increased between 9 and 15 months to levels approaching those of uninfected adults. Proportions of CCR5-expressing cells, however, were very low in cord blood and subsequently increased with age.
摘要
对暴露于人类免疫缺陷病毒但未感染的婴儿进行的横断面分析显示，其脐带血中表达CXCR4的细胞比例很高，该比例在4.5个月时下降，并在9至15个月之间增加至接近未感染成年人的水平。然而，脐带血中表达CCR5的细胞比例非常低，随后随年龄增长而增加。
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