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2
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本文引用的文献

1
Efficacy of three short-course regimens of zidovudine and lamivudine in preventing early and late transmission of HIV-1 from mother to child in Tanzania, South Africa, and Uganda (Petra study): a randomised, double-blind, placebo-controlled trial.齐多夫定与拉米夫定三种短程疗法在坦桑尼亚、南非和乌干达预防HIV-1母婴早期和晚期传播中的疗效（佩特拉研究）：一项随机、双盲、安慰剂对照试验
Lancet. 2002 Apr 6;359(9313):1178-86. doi: 10.1016/S0140-6736(02)08214-4.
2
Duration of sample storage dramatically alters expression of the human immunodeficiency virus coreceptors CXCR4 and CCR5.样本储存时长会显著改变人类免疫缺陷病毒共受体CXCR4和CCR5的表达。
Clin Diagn Lab Immunol. 2001 Mar;8(2):432-6. doi: 10.1128/CDLI.8.2.432-436.2001.
3
Up-regulation of CCR5 expression in the placenta is associated with human immunodeficiency virus-1 vertical transmission.胎盘内CCR5表达上调与人类免疫缺陷病毒1型垂直传播相关。
Am J Pathol. 2000 Dec;157(6):1811-8. doi: 10.1016/S0002-9440(10)64819-5.
4
T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV.未感染但垂直感染HIV的新生儿和儿童的T淋巴细胞成熟异常。
Blood. 2000 Dec 1;96(12):3866-71.
5
Age-dependent expression of the HIV-1 coreceptor CCR5 on CD4+ lymphocytes in children.儿童CD4+淋巴细胞上HIV-1共受体CCR5的年龄依赖性表达。
J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):285-7. doi: 10.1097/00126334-200007010-00015.
6
Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level.1型人类免疫缺陷病毒分离株在胸腺细胞中的差异嗜性和复制动力学：共受体表达允许病毒进入，但不同亚群的有效感染是在进入后水平决定的。
J Virol. 1998 Dec;72(12):9441-52. doi: 10.1128/JVI.72.12.9441-9452.1998.
7
Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progression.在体内对CC趋化因子和CXC趋化因子共受体的滥交使用的适应与HIV-1疾病进展相关。
AIDS. 1998 Sep 10;12(13):F137-43. doi: 10.1097/00002030-199813000-00001.
8
Age-related changes in blood lymphocyte subsets of Saudi Arabian healthy children.沙特阿拉伯健康儿童血液淋巴细胞亚群的年龄相关变化。
Clin Diagn Lab Immunol. 1998 Sep;5(5):632-5. doi: 10.1128/CDLI.5.5.632-635.1998.
9
Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood.1型人类免疫缺陷病毒共受体CCR5和CXCR4在脐带血和成人血来源的CD4+T细胞及单核细胞上的表达模式
AIDS Res Hum Retroviruses. 1998 May 1;14(7):607-17. doi: 10.1089/aid.1998.14.607.
10
Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features.人脐带血淋巴细胞的流式细胞术特征：免疫表型特征
Haematologica. 1998 Mar;83(3):197-203.

1型人类免疫缺陷病毒感染母亲所生未感染婴儿外周血白细胞上CXCR4和CCR5表达的年龄相关变化

Age-related changes in expression of CXCR4 and CCR5 on peripheral blood leukocytes from uninfected infants born to human immunodeficiency virus type 1-infected mothers.

作者信息

Shalekoff Sharon, Gray Glenda E, Tiemessen Caroline T

机构信息

AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, Johannesburg, South Africa.

出版信息

Clin Diagn Lab Immunol. 2004 Jan;11(1):229-34. doi: 10.1128/cdli.11.1.229-234.2004.

DOI:10.1128/cdli.11.1.229-234.2004
PMID:14715575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321339/
Abstract

Cross-sectional analysis of human immunodeficiency virus-exposed, uninfected infants revealed high proportions of CXCR4-expressing cells in their cord blood, which declined at 4.5 months and increased between 9 and 15 months to levels approaching those of uninfected adults. Proportions of CCR5-expressing cells, however, were very low in cord blood and subsequently increased with age.

摘要

对暴露于人类免疫缺陷病毒但未感染的婴儿进行的横断面分析显示，其脐带血中表达CXCR4的细胞比例很高，该比例在4.5个月时下降，并在9至15个月之间增加至接近未感染成年人的水平。然而，脐带血中表达CCR5的细胞比例非常低，随后随年龄增长而增加。