Gellein Kristin, Garruto Ralph M, Syversen Tore, Sjøbakk Torill E, Flaten Trond Peder
Department of Chemistry, Norwegian University of Science and Technology, Trondheim, Norway.
Biol Trace Elem Res. 2003 Winter;96(1-3):39-60. doi: 10.1385/BTER:96:1-3:39.
Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) are neurodegenerative disorders that occurred with extremely high frequency among the native population on Guam, especially in the 1950s and 1960s, but have substantially declined over the last half-century. The etiology of these diseases is unknown, but the most plausible hypothesis centers on imbalances in essential and toxic metals. We have determined the concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue collected during the period 1979-1983 from eight Guamanian patients with ALS, four with PDC, and five control subjects using high-resolution inductively coupled plasma-mass spectrometry. The concentrations of Cd are markedly and significantly elevated both in gray and white matter in ALS, but not in PDC patients. The concentrations of Zn are elevated for both patient groups, in both gray and white matter, but only the difference in gray matter for PDC is significant. For the other metals, no significant differences are found.
肌萎缩侧索硬化症（ALS）和帕金森病-痴呆综合征（PDC）是神经退行性疾病，在关岛原住民中发病率极高，尤其是在20世纪50年代和60年代，但在过去半个世纪中已大幅下降。这些疾病的病因尚不清楚，但最合理的假说是必需金属和有毒金属失衡。我们使用高分辨率电感耦合等离子体质谱法测定了1979年至1983年期间从8名关岛肌萎缩侧索硬化症患者、4名帕金森病-痴呆综合征患者和5名对照受试者收集的福尔马林固定脑组织中镉、钴、铜、铁、锰、铷、钒和锌的浓度。肌萎缩侧索硬化症患者灰质和白质中的镉浓度均显著升高，但帕金森病-痴呆综合征患者中未升高。两组患者灰质和白质中的锌浓度均升高，但仅帕金森病-痴呆综合征患者灰质中的差异具有统计学意义。对于其他金属，未发现显著差异。
