Suppr超能文献

丁香酚(一种存在于许多植物精油中的酚类化合物)对正常血压大鼠的心血管影响。

Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.

作者信息

Lahlou Saad, Interaminense Leylliane Fátima Leal, Magalhães Pedro Jorge Caldas, Leal-Cardoso José Henrique, Duarte Gloria Pinto

机构信息

Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.

出版信息

J Cardiovasc Pharmacol. 2004 Feb;43(2):250-7. doi: 10.1097/00005344-200402000-00013.

Abstract

Cardiovascular effects of intravenous (i.v.) treatment with eugenol (Eug), a natural pungent present in many plant essential oils, were investigated in normotensive rats. In either anesthetized or conscious rats, i.v. bolus injections of Eug (1 to 10 mg/kg) elicited immediate and dose-dependent hypotension and bradycardia. Magnitude of Eug-induced hypotension was similar in both groups. Pretreatment of anesthetized rats with bilateral vagotomy almost abolished the bradycardic responses to Eug without affecting the hypotension. Likewise, i.v. pretreatment of conscious rats with methylatropine (1 mg/kg) or hexamethonium (30 mg/kg) significantly reduced the Eug-induced bradycardia without affecting the hypotension. However, i.v. pretreatment with the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl (L-NAME, 20 mg/kg), affected neither the hypotension nor the bradycardia elicited by Eug. In rat mesenteric bed preparations precontracted with potassium (60 mM), Eug (0.1-2 mM) induced a reversible and concentration-dependent vasodilator effect, which remained unaffected by atropine (1 microM). These results show that i.v. treatment of rats with Eug induces dose-dependent hypotension and bradycardia, which occurred independently. The bradycardia appears dependent upon the presence of an intact and functional parasympathetic nerve drive to the heart while the hypotension is due to an active vascular relaxation rather than withdrawal of sympathetic tone. Released nitric oxide from vascular endothelial cells seems to be not involved in the mediation of Eug-induced hypotension.

摘要

丁香酚(Eug)是许多植物精油中存在的一种天然刺激性物质,研究了其静脉注射(i.v.)对正常血压大鼠的心血管影响。在麻醉或清醒的大鼠中,静脉推注丁香酚(1至10毫克/千克)会引起立即且剂量依赖性的低血压和心动过缓。两组中丁香酚引起的低血压程度相似。对麻醉大鼠进行双侧迷走神经切断术预处理几乎消除了对丁香酚的心动过缓反应,而不影响低血压。同样,对清醒大鼠静脉注射甲基阿托品(1毫克/千克)或六甲铵(3毫克/千克)预处理可显著降低丁香酚引起的心动过缓,而不影响低血压。然而,静脉注射一氧化氮合酶抑制剂NG-硝基-L-精氨酸甲酯(L-NAME,20毫克/千克)既不影响丁香酚引起的低血压,也不影响心动过缓。在预先用钾(60毫摩尔)预收缩的大鼠肠系膜床制剂中,丁香酚(0.1-2毫摩尔)诱导出可逆的浓度依赖性血管舒张作用,该作用不受阿托品(1微摩尔)的影响。这些结果表明,静脉注射丁香酚对大鼠诱导出剂量依赖性的低血压和心动过缓,且二者独立发生。心动过缓似乎依赖于完整且功能正常的心脏副交感神经驱动的存在,而低血压是由于主动的血管舒张而非交感神经张力的降低。血管内皮细胞释放的一氧化氮似乎不参与丁香酚诱导的低血压的介导。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验