Interaminense Leylliane Fátima Leal, Leal-Cardoso José Henrique, Magalhães Pedro Jorge Caldas, Duarte Gloria Pinto, Lahlou Saad
Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Pernambuco-PE, Brazil.
Planta Med. 2005 Apr;71(4):376-8. doi: 10.1055/s-2005-864109.
The cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Ocimum gratissimum (EOOG) and its main constituent, eugenol (Eug) were investigated in the experimental model of deoxycorticosterone acetate (DOCA-salt)-hypertensive rats. In both conscious DOCA-salt hypertensive rats and their uninephrectomized controls, i.v. bolus injections of EOOG (1 - 20 mg/kg) or Eug (1 - 10 mg/kg) induced dose-dependent hypotension and bradycardia. Treatment with DOCA-salt significantly enhanced the maximal decreases in mean aortic pressure (MAP) elicited by hexamethonium (30 mg/kg, i.v.) as well as the hypotensive responses to both EOOG and Eug without affecting the bradycardia. However, the enhancement of EOOG-induced hypotension in hypertensive rats remained unaffected by i.v. pretreatment with either hexamethonium (30 mg/kg) or methylatropine (1 mg/kg). These results show that i.v. treatment with EOOG or Eug dose-dependently decreased blood pressure in conscious DOCA-salt hypertensive rats, and this action is enhanced when compared with uninephrectomized controls. This enhancement appears related mainly to an increase in EOOG-induced vascular smooth relaxation rather than to enhanced sympathetic nervous system activity in this hypertensive model.
在醋酸脱氧皮质酮（DOCA-盐）诱导的高血压大鼠实验模型中，研究了丁香罗勒精油（EOOG）及其主要成分丁香酚（Eug）静脉注射治疗的心血管效应。在清醒的DOCA-盐高血压大鼠及其单侧肾切除的对照大鼠中，静脉推注EOOG（1 - 20 mg/kg）或Eug（1 - 10 mg/kg）均可引起剂量依赖性的低血压和心动过缓。DOCA-盐处理显著增强了六甲铵（30 mg/kg，静脉注射）引起的平均主动脉压（MAP）最大降幅，以及对EOOG和Eug的降压反应，而不影响心动过缓。然而，高血压大鼠中EOOG诱导的低血压增强不受六甲铵（30 mg/kg）或甲基阿托品（1 mg/kg）静脉预处理的影响。这些结果表明，静脉注射EOOG或Eug可使清醒的DOCA-盐高血压大鼠血压呈剂量依赖性降低，与单侧肾切除的对照大鼠相比，这种作用有所增强。这种增强主要似乎与EOOG诱导的血管平滑肌舒张增加有关，而不是与该高血压模型中交感神经系统活动增强有关。
