卡马西平和触发区在三叉神经痛中的诊断意义

Diagnostic significance of carbamazepine and trigger zones in trigeminal neuralgia.

作者信息

Sato Jun, Saitoh Tohru, Notani Ken-Ichi, Fukuda Hiroshi, Kaneyama Keiseki, Segami Natsuki

机构信息

Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Japan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jan;97(1):18-22. doi: 10.1016/j.tripleo.2003.08.003.

DOI:10.1016/j.tripleo.2003.08.003

PMID:14716252

Abstract

OBJECTIVE

To investigate the relationship between the efficacy of carbamazepine (CBZ) and the presence of the trigger zone for diagnosis of trigeminal neuralgia (TN). Study design CBZ was administered to 61 patients with suspected TN. All patients underwent intracranial examination by magnetic resonance imaging or computed tomography. The final diagnosis was established by oral and maxillofacial surgeon and neurosurgeon.

RESULTS

Of the 61 patients, 50 were finally diagnosed as having TN and 6 as having atypical facial pain. CBZ was effective for pain relief in 45 of the 50 TN patients (90%), and in 5 of the 11 patients (45%) with other diseases (P <.005). However, CBZ also relieved pain in some patients other than TN. Thirty of the 31 patients (97%) with a distinct trigger zone and 20 of the 30 (67%) without a trigger zone were diagnosed as having TN (P<0.005).

CONCLUSION

The efficacy of CBZ is an auxiliary indicator of TN and the presence of a distinct trigger zone is a strong indicator of TN.

摘要

目的

探讨卡马西平（CBZ）疗效与三叉神经痛（TN）诊断触发区存在之间的关系。研究设计：对61例疑似TN患者给予CBZ治疗。所有患者均接受磁共振成像或计算机断层扫描颅内检查。最终诊断由口腔颌面外科医生和神经外科医生确定。

结果

61例患者中，50例最终诊断为TN，6例诊断为非典型面部疼痛。50例TN患者中有45例（90%）使用CBZ后疼痛缓解，11例其他疾病患者中有5例（45%）疼痛缓解（P<.005）。然而，CBZ也能缓解一些非TN患者的疼痛。31例有明显触发区的患者中有30例（97%）诊断为TN，30例无触发区的患者中有20例（67%）诊断为TN（P<0.005）。