Cicarelli G, Della Rocca G, Amboni M, Ciacci C, Mazzacca G, Filla A, Barone P
Department of Neurological Sciences, Federico II University of Naples, Via S. Pansini 5, I-80131 Naples, Italy.
Neurol Sci. 2003 Dec;24(5):311-7. doi: 10.1007/s10072-003-0181-4.
We assessed the occurrence of neurological signs and symptoms in adult patients with celiac disease and evaluated the correlation between neurological features and diet. A total of 176 patients and 52 age-matched controls underwent a semistructural interview and a neurologic examination. The effect of gluten-free diet was evaluated by comparing the prevalence of signs and symptoms among patients adhering to a gluten-free diet and patients on an unrestricted diet. The occurrence of headache, dysthymia and signs of peripheral neuropathy was significantly higher in patients with celiac disease than in control subjects. Adherence to a strict gluten-free diet was associated with a significant reduction of headache, dysthymia, cramps and weakness, but did not modify the occurrence of paresthesia or hyporeflexia. Neurological signs and symptoms are associated with celiac disease and can be ameliorated by a gluten-free diet.
我们评估了成年乳糜泻患者神经体征和症状的发生率，并评估了神经特征与饮食之间的相关性。共有176例患者和52例年龄匹配的对照者接受了半结构式访谈和神经学检查。通过比较坚持无麸质饮食的患者和饮食不受限制的患者中体征和症状的患病率，评估无麸质饮食的效果。乳糜泻患者头痛、心境恶劣和周围神经病变体征的发生率显著高于对照组。坚持严格的无麸质饮食与头痛、心境恶劣、痉挛和虚弱的显著减轻相关，但并未改变感觉异常或反射减退的发生率。神经体征和症状与乳糜泻相关，无麸质饮食可使其改善。
