Mir P, Alberca R, Navarro A, Montes E, Martínez E, Franco E, Cayuela A, Lozano P
Department of Neurology, University Hospital Virgen del Rocío, Avda. Manuel Siurot s/n, 41013 Seville, Spain.
Neurol Sci. 2003 Dec;24(5):318-21. doi: 10.1007/s10072-003-0182-3.
We evaluated the efficacy of intravenous boluses of methylprednisolone followed by prednisone as a prophylactic treatment for episodic cluster headache. Fourteen male patients (mean age, 42.54 years) with episodic cluster headache were treated with 250-mg boluses of methylprednisolone on 3 consecutive days, followed by prednisone (90 mg/day orally) with gradual tapering in four weeks. Headache parameters of the active phases treated with methylprednisolone were compared with those of previous active phases in the same patients treated with other prophylactic medications. The primary efficacy criterion was decrease in the frequency of attacks during the first month of treatment. The statistical differences were calculated using Wilcoxon's test. The attacks were significantly less frequent in the active phases treated with methylprednisolone boluses than those treated with other medications ( p<0.05). This treatment seems to be more effective than the usual prophylactic treatments for episodic cluster headache.
我们评估了静脉注射甲泼尼龙随后口服泼尼松作为发作性丛集性头痛预防性治疗的疗效。14名发作性丛集性头痛男性患者（平均年龄42.54岁）连续3天接受250毫克甲泼尼龙静脉推注治疗，随后口服泼尼松（90毫克/天），并在四周内逐渐减量。将接受甲泼尼龙治疗的活跃期头痛参数与同一患者先前接受其他预防性药物治疗的活跃期参数进行比较。主要疗效标准是治疗第一个月内发作频率的降低。使用Wilcoxon检验计算统计学差异。接受甲泼尼龙静脉推注治疗的活跃期发作频率明显低于接受其他药物治疗的活跃期（p<0.05）。这种治疗似乎比发作性丛集性头痛的常规预防性治疗更有效。
