Dinsmoor M J, Christmas J T
Department of Obstetrics and Gynecology, Medical College of Virginia/Virginia Commonwealth University.
Am J Obstet Gynecol. 1992 Dec;167(6):1575-9. doi: 10.1016/0002-9378(92)91743-t.
We describe changes in T-lymphocyte subpopulations in pregnancies complicated by human immunodeficiency virus infection.
T-lymphocyte counts were performed every trimester and post partum on all patients with human immunodeficiency virus infection. Patients with a CD4 count < 500 cells/mm3 were offered zidovudine after the first trimester. We performed a regression analysis of repeated measures on the total lymphocyte, CD4, and CD8 counts.
Twenty-three patients were studied, 10 (43%) of whom took zidovudine. CD4, CD8, and total lymphocyte counts decreased in patients not taking zidovudine but remained stable in patients receiving zidovudine. The differences were not statistically significant.
CD4 and CD8 counts may decrease during pregnancies complicated by human immunodeficiency virus infection, primarily because of decreases in the total lymphocyte count. The use of zidovudine may prevent this decline. The clinical use of absolute CD4 counts during pregnancy requires further study.
我们描述了合并人类免疫缺陷病毒感染的妊娠中T淋巴细胞亚群的变化。
对所有人类免疫缺陷病毒感染患者在孕早期、孕中期、孕晚期及产后进行T淋巴细胞计数。孕早期后，对CD4细胞计数<500个/立方毫米的患者给予齐多夫定治疗。我们对总淋巴细胞、CD4和CD8计数进行了重复测量的回归分析。
共研究了23例患者，其中10例（43%）服用了齐多夫定。未服用齐多夫定的患者CD4、CD8和总淋巴细胞计数下降，而接受齐多夫定治疗的患者这些指标保持稳定。差异无统计学意义。
合并人类免疫缺陷病毒感染的妊娠期间，CD4和CD8计数可能下降，主要是由于总淋巴细胞计数减少。使用齐多夫定可能预防这种下降。孕期绝对CD4计数的临床应用需要进一步研究。
