影响宫颈阴道上皮细胞脱落的因素。

Factors influencing the exfoliation of cervicovaginal epithelial cells.

作者信息

Basu J, Mikhail M S, Palan P R, Payraudeau P H, Romney S L

机构信息

Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461.

出版信息

Am J Obstet Gynecol. 1992 Dec;167(6):1904-9. doi: 10.1016/0002-9378(92)91795-c.

DOI:10.1016/0002-9378(92)91795-c

PMID:1471715

Abstract

OBJECTIVE

Our objective was to investigate the association of smoking and exfoliation of cervicovaginal epithelial cells while controlling for other factors that may potentially influence cell exfoliation (e.g., presence of cervical intraepithelial neoplasia or koilocytes, the use of oral contraceptives, age, and the phase of the menstrual cycle).

STUDY DESIGN

Cervicovaginal lavage specimens and epidemiologic questionnaires were obtained with informed consent from 190 women. The cervicovaginal lavage samples were processed to separate other contaminants. The number of squamous epithelial cells counted was expressed as cells per milliliter of lavage.

RESULTS

Multiple linear regression analysis revealed that the number of exfoliated epithelial cells was significantly higher in smokers (p < 0.01) and also in women with cervical intraepithelial neoplasia (p < 0.05). The other studied variables had no detectable effect.

CONCLUSION

The findings suggest that smoking or the presence of cervical intraepithelial neoplasia may induce an acceleration in the exfoliation of cervicovaginal epithelial cells. This may alter cell maturation and may be a factor in the oncogenic process.

摘要