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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.在Tbk1基因缺陷的小鼠胚胎成纤维细胞中，干扰素调节因子3依赖性基因表达存在缺陷。
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):233-8. doi: 10.1073/pnas.2237236100. Epub 2003 Dec 16.
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Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.含Toll/IL-1受体结构域的衔接蛋白诱导干扰素-β（TRIF）与肿瘤坏死因子受体相关因子6和TANK结合激酶1结合，并在Toll样受体信号传导中激活两种不同的转录因子，即核因子-κB和干扰素调节因子3。
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.脂多糖- Toll样受体4（LPS-TLR4）向干扰素调节因子3/7（IRF-3/7）和核因子κB（NF-κB）的信号传导涉及Toll衔接蛋白TRAM和TRIF。
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Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells.浆细胞样树突状细胞通过Toll样受体9介导对单纯疱疹病毒2的识别。
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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.鉴定Lps2为不依赖MyD88的TIR信号传导的关键转导分子。
Nature. 2003 Aug 14;424(6950):743-8. doi: 10.1038/nature01889. Epub 2003 Jul 20.
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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.衔接蛋白TRIF在不依赖MyD88的Toll样受体信号通路中的作用。
Science. 2003 Aug 1;301(5633):640-3. doi: 10.1126/science.1087262. Epub 2003 Jul 10.
8
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.病毒感染可将非浆细胞样树突状细胞转变为高效干扰素产生细胞。
Nature. 2003 Jul 17;424(6946):324-8. doi: 10.1038/nature01783. Epub 2003 Jun 22.
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Science. 2003 May 16;300(5622):1148-51. doi: 10.1126/science.1081315. Epub 2003 Apr 17.

Unexpected similarities in cellular responses to bacterial and viral invasion.

作者信息

Pitha Paula M

机构信息

Sidney Kimmel Cancer Center and Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

出版信息

Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):695-6. doi: 10.1073/pnas.0307303101. Epub 2004 Jan 12.

DOI:10.1073/pnas.0307303101
PMID:14718669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321741/
Abstract
摘要