Unexpected similarities in cellular responses to bacterial and viral invasion.
作者信息
Pitha Paula M
机构信息
Sidney Kimmel Cancer Center and Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):695-6. doi: 10.1073/pnas.0307303101. Epub 2004 Jan 12.
Abstract
摘要
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Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.脂多糖和双链RNA诱导的共刺激分子上调通过依赖Trif和不依赖Trif的途径发生。
Nat Immunol. 2003 Dec;4(12):1223-9. doi: 10.1038/ni1010. Epub 2003 Nov 16.
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Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.含Toll/IL-1受体结构域的衔接蛋白诱导干扰素-β（TRIF）与肿瘤坏死因子受体相关因子6和TANK结合激酶1结合，并在Toll样受体信号传导中激活两种不同的转录因子，即核因子-κB和干扰素调节因子3。
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