Hohlfeld R, Engel A G
Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905.
Ann Neurol. 1992 Dec;32(6):821-3. doi: 10.1002/ana.410320619.
In normal muscle, 65-kd heat shock proteins (hsp) were detected on capillary endothelial cells, the mural elements of larger vessels, and some intracellular organelles, probably mitochondria. In the inflammatory myopathies, the 65-kd hsp were detected on inflammatory cells, degenerating and regenerating fibers, and on many but not all nonnecrotic muscle fibers invaded by T cells. The expression of the 65-kd hsp may be an immune-nonspecific response to cellular "stress," but hsp determinants could possibly also serve as autoantigen(s) recognized by autoreactive T cells.
在正常肌肉中，在毛细血管内皮细胞、较大血管的壁成分以及一些细胞内细胞器（可能是线粒体）上检测到了65-kd热休克蛋白（hsp）。在炎性肌病中，在炎性细胞、变性和再生纤维以及许多但并非所有被T细胞侵入的非坏死性肌纤维上检测到了65-kd hsp。65-kd hsp的表达可能是对细胞“应激”的免疫非特异性反应，但hsp决定簇也可能作为自身反应性T细胞识别的自身抗原。
