“朗格汉斯细胞组织细胞增多症细胞”的同种异体抗原呈递能力缺陷
Defective alloantigen-presenting capacity of 'Langerhans cell histiocytosis cells'.
作者信息
Yu R C, Morris J F, Pritchard J, Chu T C
机构信息
Unit of Dermatology, Royal Postgraduate Medical School, London.
出版信息
Arch Dis Child. 1992 Nov;67(11):1370-2. doi: 10.1136/adc.67.11.1370.
Abstract
The functional activity of skin cells derived from an infant who died of multisystem Langerhans cell histiocytosis (LCH) was examined. Involved and non-involved skin was obtained at postmortem examination within three hours of death; normal epidermal Langerhans cells and 'LCH cells' were separated by means of dispase digestion. The functional activity of different populations of CD1a positive cells was assessed using the conventional six day allogeneic mixed cell reaction. Compared with Langerhans cells from a healthy control, LCH cells showed minimal functional activity. However, Langerhans cells from non-involved skin showed normal and Langerhans cells overlying involved skin showed augmented functional activity. These findings suggest that LCH is a disease in which abnormal Langerhans cells accumulate and/or proliferate in various tissues but it does not affect the entire Langerhans cell population.
摘要
对一名死于多系统朗格汉斯细胞组织细胞增多症（LCH）的婴儿的皮肤细胞功能活性进行了检测。在死后三小时内的尸检中获取了受累和未受累皮肤；通过Dispase消化分离出正常表皮朗格汉斯细胞和“LCH细胞”。使用传统的六天同种异体混合细胞反应评估不同群体CD1a阳性细胞的功能活性。与健康对照的朗格汉斯细胞相比，LCH细胞显示出最小的功能活性。然而，未受累皮肤的朗格汉斯细胞显示正常，而覆盖受累皮肤的朗格汉斯细胞显示功能活性增强。这些发现表明，LCH是一种异常朗格汉斯细胞在各种组织中积聚和/或增殖但不影响整个朗格汉斯细胞群体的疾病。
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