Upadhyay Juhi, Upadhyay Ram B, Agrawal Pankaj, Jaitley Shweta, Shekhar Rhitu
Department of Oral and Maxillofacial Pathology, K.D. Dental College and Hospital, Mathura, India.
N Am J Med Sci. 2013 Sep;5(9):505-14. doi: 10.4103/1947-2714.118923.
Dendritic cells are arguably the most potent antigen-presenting cells and may be the only cells capable of initiating the adaptive immune response. The epithelial residents of dendritic cells are Langerhans cells, which serve as the "sentinels" of the mucosa, altering the immune system not only to pathogen entry but also of tolerance to self antigen and commensal microbes. Oral mucosal Langerhans cells are capable of engaging and internalizing a wide variety of pathogens and have been found responsive to nickel in patients with nickel allergies, oral Candida species, oral lichen planus, lichenoid drug eruptions, graft versus host diseases, periodontal diseases median rhomboid glossitis, human immunodeficiency virus infection, hairy leukoplakia of the tongue, and oral squamous cell carcinoma. Review focuses on the role of antigen-presenting cells in particular Langerhans cells to better understand the mechanisms underlying immune responses. In this review, comprehensive detail about mucosal diseases has been compiled using the PubMed database and through textbooks.
树突状细胞可以说是最强大的抗原呈递细胞，可能是唯一能够启动适应性免疫反应的细胞。树突状细胞的上皮驻留细胞是朗格汉斯细胞，它们作为黏膜的“哨兵”，不仅能使免疫系统对病原体的侵入做出反应，还能改变对自身抗原和共生微生物的耐受性。口腔黏膜朗格汉斯细胞能够捕获和内化多种病原体，并且在镍过敏患者、口腔念珠菌属、口腔扁平苔藓、苔藓样药疹、移植物抗宿主病、牙周病、正中菱形舌炎、人类免疫缺陷病毒感染、舌部毛状白斑和口腔鳞状细胞癌患者中已发现对镍有反应。综述着重于抗原呈递细胞尤其是朗格汉斯细胞的作用，以更好地理解免疫反应的潜在机制。在本综述中，使用PubMed数据库并通过教科书汇编了有关黏膜疾病的全面详细信息。
