树突状细胞：免疫发病机制与疫苗研发前沿——综述

Mohamadzadeh Mansour, Luftig Ronald

Department of Medicine, Tulane University Health Science Center, New Orleans, USA.

J Immune Based Ther Vaccines. 2004 Jan 13;2(1):1. doi: 10.1186/1476-8518-2-1.

Dendritic cellls (DCs) comprise an essential component of the immune system. These cells, as antigen presenting cells (APCs) to naïve T cells, are crucial in the initiation of antigen specific immune responses. In the past years, several DC subsets have been identified in different organs which exert different effects in order to elicit adaptive immune responses. Thus, identification of such DC subsets has led to a better understanding of their distribution and function in the body. In this review, several key properties of the immunobiology, immunopathogenesis and vaccine strategies using DCs will be discussed.

树突状细胞（DCs）是免疫系统的重要组成部分。这些细胞作为初始T细胞的抗原呈递细胞（APCs），在抗原特异性免疫反应的启动中起着关键作用。在过去几年中，已在不同器官中鉴定出几种DC亚群，它们发挥不同作用以引发适应性免疫反应。因此，对这些DC亚群的鉴定有助于更好地了解它们在体内的分布和功能。在本综述中，将讨论DCs免疫生物学、免疫发病机制和疫苗策略的几个关键特性。