De Bacquer Dirk, De Backer Guy, Cokkinos Dennis, Keil Ulrich, Montaye Michèle, Ostör Erika, Pyörälä Kalevi, Sans Susana
Department of Public Health, Ghent University, Ghent, Belgium.
Eur Heart J. 2004 Jan;25(2):121-8. doi: 10.1016/j.ehj.2003.10.024.
Several epidemiological studies have reported increasing obesity rates in the general population during last decades. We studied the prevalence of overweight and obesity in the high priority group of patients with established coronary heart disease (CHD) and the therapeutic control of manageable coronary risk factors in relation to body mass index.
Data from a representative sample of patients having experienced a recent cardiac event before the age of 71 years from 15 European centres participating in the EUROASPIRE II study, were gathered in the period 1999-2000 through standardized methods. In total, 5535 coronary patients with valid height and weight measurements were included.
About one in three patients (31%) was diagnosed as obese with additionally half of the patient population being overweight (48%). Obesity was 10% more prevalent among women and significantly less smokers were observed among overweight and obese subjects, twice as many diabetics and more people with low education. Overweight and obese patients had more frequently raised blood pressure and elevated cholesterol after adjustment for age, gender, education, diabetes and centre. In patients using blood pressure lowering agents, 56% of obese and 51% of overweight patients were still having raised blood pressure compared to 42% in normal weight patients. A similar result was observed for the therapeutic control of total cholesterol. Since their hospital discharge, obese and overweight patients did not alter lifestyles regarding fat intake and physical activity. In the period between coronary event and interview, body weight had increased with at least five kilograms in a quarter of all patients.
These results suggest that the growing population of overweight and obese coronary patients is at particularly high risk for further cardiovascular complications due to elevated risk factor levels on the one hand and their insufficient therapeuticcontrol on the other hand. Our results also confirm the considerable weight gain seen in a high proportion of patients following their cardiac event.
多项流行病学研究报告称,在过去几十年中,普通人群的肥胖率不断上升。我们研究了确诊冠心病(CHD)的高优先级患者群体中超重和肥胖的患病率,以及与体重指数相关的可控冠心病危险因素的治疗控制情况。
1999年至2000年期间,通过标准化方法收集了参与EUROASPIRE II研究的15个欧洲中心71岁之前近期发生心脏事件患者的代表性样本数据。总共纳入了5535例有有效身高和体重测量值的冠心病患者。
约三分之一的患者(31%)被诊断为肥胖,另有一半患者超重(48%)。肥胖在女性中更为普遍,超重和肥胖患者中吸烟者明显较少,糖尿病患者是正常人的两倍,且低学历人群更多。在对年龄、性别、教育程度、糖尿病和中心进行调整后,超重和肥胖患者的血压升高和胆固醇升高更为常见。在使用降压药的患者中,肥胖患者中有56%、超重患者中有51%的血压仍高于正常体重患者中的42%。总胆固醇的治疗控制也观察到了类似结果。自出院以来,肥胖和超重患者在脂肪摄入和身体活动方面的生活方式没有改变。在冠心病事件至访谈期间,四分之一的患者体重增加了至少5公斤。
这些结果表明,超重和肥胖的冠心病患者群体不断增加,一方面由于危险因素水平升高,另一方面由于治疗控制不足,他们面临进一步心血管并发症的风险特别高。我们的结果还证实了相当一部分患者在心脏事件后体重显著增加。