Smit Jennifer, Botha Julia, McFadyen Lynn, Beksinska Mags
Department of Obstetrics and Gynaecology, University of the Witwatersrand, Suite 1301, Maritime House, 143 Salmon Grove, Durban, 4001, South Africa.
Contraception. 2004 Jan;69(1):3-7. doi: 10.1016/j.contraception.2003.09.005.
In the absence of published data on serum medroxyprogesterone acetate (MPA) levels in South African users, this study examines such levels in new and repeat users of depot medroxyprogesterone acetate at the end of the dosing interval. The study was undertaken at three family-planning clinics in Durban, South Africa. Serum MPA levels were measured in 94 Black African, Indian and White women returning between 11 and 14 weeks after their last injection. The median serum MPA level was 0.88 (range, <0.04-1.77) ng/mL and wide interindividual variability was observed. Levels in all but one woman were higher than 0.1 ng/mL, the level at which ovulation is reported to resume. MPA levels were not found to vary according to weight, body mass index or ethnicity. Although there was a slight tendency towards higher MPA levels with longer duration of use (r = 0.13), the wide interindividual variability precluded the possibility of determining whether this was a real trend. A prospective study, using standardized assay techniques and following individual women, is required to further clarify this issue.
由于缺乏关于南非醋酸甲羟孕酮（MPA）使用者血清水平的已发表数据，本研究在给药间隔结束时检测了醋酸甲羟孕酮长效注射剂新使用者和重复使用者的血清MPA水平。该研究在南非德班的三家计划生育诊所进行。对94名在最后一次注射后11至14周回访的黑人非洲、印度和白人女性测量了血清MPA水平。血清MPA水平中位数为0.88（范围，<0.04 - 1.77）ng/mL，观察到个体间差异较大。除一名女性外，所有女性的MPA水平均高于0.1 ng/mL，据报道该水平会使排卵恢复。未发现MPA水平因体重、体重指数或种族而有所不同。尽管随着使用时间延长MPA水平有轻微升高趋势（r = 0.13），但个体间差异较大使得无法确定这是否为真实趋势。需要采用标准化检测技术并跟踪个体女性进行前瞻性研究以进一步阐明该问题。
