Bonny Andrea E, Lange Hannah L H, Rogers Lynette K, Gothard Dave M, Reed Michael D
Nationwide Children's Hospital, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Contraception. 2014 May;89(5):357-60. doi: 10.1016/j.contraception.2014.01.017. Epub 2014 Feb 1.
To explore the relationship between medroxyprogesterone acetate (MPA) pharmacokinetic (PK) parameter estimates and weight gain.
Prospective study of adolescents (N=40; age 12-21 years) initiating DMPA. PK parameters were calculated: maximum MPA concentration (Cmax, ng/mL), time to Cmax (Tmax, days) and elimination rate constant (ng/mL/day). Optimal PK cut points were determined for predicting body mass index (BMI) increase ≥10%.
Cmax <2.88 ng/mL and elimination rate constant <0.021 ng/mL/day were associated (p<.05) with BMI increase ≥10%. Elimination rate constant was most predictive of weight gain.
PK evaluation may help identify adolescents at risk of excessive DMPA-associated weight gain.
探讨醋酸甲羟孕酮（MPA）药代动力学（PK）参数估计值与体重增加之间的关系。
对开始使用醋酸甲羟孕酮避孕针（DMPA）的青少年（N = 40；年龄12 - 21岁）进行前瞻性研究。计算PK参数：MPA最大浓度（Cmax，ng/mL）、达到Cmax的时间（Tmax，天）和消除速率常数（ng/mL/天）。确定用于预测体重指数（BMI）增加≥10%的最佳PK切点。
Cmax <2.88 ng/mL和消除速率常数<0.021 ng/mL/天与BMI增加≥10%相关（p<.05）。消除速率常数对体重增加的预测性最强。
PK评估可能有助于识别有DMPA相关体重过度增加风险的青少年。
