Wiegratz I, Hommel H H, Zimmermann T, Kuhl H
Center of Obstetrics and Gynecology, University Hospital of Frankfurt, am Main, Frankfurt, Germany.
Contraception. 2004 Jan;69(1):37-42. doi: 10.1016/j.contraception.2003.09.004.
Long-cycle regimens with continuous use of oral contraceptives (OCs) for 3 or 6 months followed by a hormone-free interval of 7 days may reduce or prevent cycle-dependent and menses-related complaints. A representative survey carried out with 1195 German women in different age groups revealed that only 26-35% of the women aged between 15 and 49 years preferred monthly bleeding, while 37-46% wished to never bleed. The reasons for the refusal of regular menstruations were fewer severe menstrual complaints, better hygiene, higher quality of life, and less blood loss. Among the women who preferred regular withdrawal bleeding during the use of OCs, the main reasons were fear of pregnancy, infertility and adverse effects, and that menstruations were natural. Between 32% and 54% of the women would suppress menstruation sporadically and 11-14% for a longer period of time. After continuous treatment with a combination of 30 microg ethinyl estradiol and 2 mg dienogest for 6 months, the majority of women preferred the long-cycle regimen as compared to the conventional OC regimen despite a higher rate of irregular bleeding. Bleeding occurred primarily in first-time users of OC, particularly during the administration of the second OC pack. A survey carried out with German gynecologists revealed that most physicians prescribed extended OC cycles primarily for medical reasons, e.g., dysmenorrhea, hypermenorrhea, endometriosis and premenstrual dysphoric disorder. The gynecologists preferred a regimen with three packs of extended use of OCs.
连续服用口服避孕药（OCs）3个月或6个月，随后有7天无激素间隔期的长周期方案，可能会减少或预防与月经周期和月经相关的不适。一项对1195名不同年龄组德国女性进行的代表性调查显示，在15至49岁的女性中，只有26% - 35%的女性更喜欢每月来月经，而37% - 46%的女性希望永远不来月经。拒绝规律月经的原因包括严重月经不适较少、卫生状况更好、生活质量更高以及失血更少。在使用OCs期间更喜欢规律撤退性出血的女性中，主要原因是担心怀孕、不孕和不良反应，以及认为月经是自然现象。32%至54%的女性会偶尔抑制月经，11% - 14%的女性会在较长时间内抑制月经。在连续6个月使用30微克炔雌醇和2毫克地诺孕素联合治疗后，尽管不规则出血率较高，但与传统OC方案相比，大多数女性更喜欢长周期方案。出血主要发生在首次使用OCs的女性中，尤其是在服用第二包OCs期间。一项对德国妇科医生进行的调查显示，大多数医生主要出于医学原因，如痛经、月经过多、子宫内膜异位症和经前烦躁障碍，而开出延长OC周期的处方。妇科医生更喜欢使用三包延长使用期OCs的方案。
