Rotzsch W, Richter V, Rassoul F, Walper A
Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universität Leipzig.
Arzneimittelforschung. 1992 Oct;42(10):1223-7.
Postprandial Lipaemia under Treatment with Allium sativum/Controlled double-blind study in healthy volunteers with reduced HDL2-cholesterol levels. The effectiveness of a standardized garlic powder preparation (Sapec, Kwai) on alimentary hypertriglyceridaemia after intake of a standardized fatty test meal containing 100 g butter was analyzed in a randomized placebo-controlled double-blind study. 24 volunteers with HDL2-cholesterol concentrations in plasma of less than 10 mg/dl (men) respectively 15 mg/dl (women) participated in the study. The volunteers received 3 times 1 tablet daily over a period of 6 weeks equivalent to a daily dosage of 900 mg garlic powder in the active treated group. Control measurements were made on the 1st, 22nd and 43rd day of treatment and 0, 3 and 5 h after intake of the meal. The postprandial increase of triglycerides was clearly reduced under garlic medication as compared to placebo treatment. The determined AUC-values for the triglycerides were up to 35% lower in the garlic group compared to the placebo group. The regular intake of the garlic preparation over the period of 6 weeks showed a significant lowering of the fasting values of triglycerides in comparison to placebo. Under garlic medication HDL2-cholesterol increased more than under placebo in tendency.
大蒜治疗餐后血脂异常/对高密度脂蛋白2胆固醇水平降低的健康志愿者进行的对照双盲研究。在一项随机安慰剂对照双盲研究中，分析了一种标准化大蒜粉制剂（Sapec，蒜卫士）对摄入含100克黄油的标准化脂肪试验餐后饮食性高甘油三酯血症的疗效。24名血浆高密度脂蛋白2胆固醇浓度男性低于10毫克/分升、女性低于15毫克/分升的志愿者参与了该研究。在活性治疗组中，志愿者在6周内每天服用3次，每次1片，相当于每日服用900毫克大蒜粉。在治疗的第1天、第22天和第43天以及进食后0、3和5小时进行对照测量。与安慰剂治疗相比，大蒜用药后餐后甘油三酯的升高明显降低。大蒜组甘油三酯的测定曲线下面积值比安慰剂组低35%。与安慰剂相比，在6周内定期服用大蒜制剂可显著降低甘油三酯的空腹值。大蒜用药后高密度脂蛋白2胆固醇有比安慰剂组升高更多的趋势。
