Plusquellec Y, Houin G
Unité de Formation et de Recherches de Mathématiques, Université Paul Sabatier, Toulouse, France.
Arzneimittelforschung. 1992 Oct;42(10):1259-61.
When a drug is simultaneously given extravascularly and intravenously, the plasma concentration reaches a maximum at a time Tmax. The purpose of this paper is to get the amount of the drug remaining in the body at this time Tmax. Furthermore, mean residence time of the drug and the area under concentration curve are given.
当一种药物同时通过血管外途径和静脉途径给药时,血浆浓度在时间Tmax达到最大值。本文的目的是求出在这个时间Tmax时体内剩余的药物量。此外,还给出了药物的平均驻留时间和浓度曲线下的面积。