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骨髓留下了它的痕迹：肺纤维化的新概念。

The bone marrow leaves its scar: new concepts in pulmonary fibrosis.

作者信息

Dunsmore Sarah E, Shapiro Steven D

机构信息

Respiratory and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

J Clin Invest. 2004 Jan;113(2):180-2. doi: 10.1172/JCI20782.

DOI:10.1172/JCI20782
PMID:14722608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC311440/
Abstract

Excess collagen deposition occurs in pulmonary fibrosis. A new study suggests that collagen overproduction may originate from cells derived from bone marrow precursors rather than parenchymal lung fibroblasts.

摘要

肺纤维化中会出现胶原蛋白过度沉积的情况。一项新研究表明，胶原蛋白的过度产生可能源自骨髓前体细胞而非肺实质成纤维细胞。

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The bone marrow leaves its scar: new concepts in pulmonary fibrosis.骨髓留下了它的痕迹：肺纤维化的新概念。
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本文引用的文献

1
Bone marrow-derived progenitor cells in pulmonary fibrosis.肺纤维化中的骨髓源性祖细胞。
J Clin Invest. 2004 Jan;113(2):243-52. doi: 10.1172/JCI18847.
2
Plasticity of marrow-derived stem cells.骨髓来源干细胞的可塑性。
Blood. 2003 Nov 15;102(10):3483-93. doi: 10.1182/blood-2003-05-1664. Epub 2003 Jul 31.
3
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.博来霉素暴露可增强间充质干细胞在肺中的植入，并改善其纤维化作用。
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8407-11. doi: 10.1073/pnas.1432929100. Epub 2003 Jun 18.
4
Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis.放射性肺纤维化中肌成纤维细胞的骨髓起源
Am J Respir Cell Mol Biol. 2003 Aug;29(2):213-24. doi: 10.1165/rcmb.2002-0069OC. Epub 2003 Mar 20.
5
Evidence that fibroblasts derive from epithelium during tissue fibrosis.在组织纤维化过程中，成纤维细胞来源于上皮细胞的证据。
J Clin Invest. 2002 Aug;110(3):341-50. doi: 10.1172/JCI15518.
6
Bone marrow-derived cells as progenitors of lung alveolar epithelium.作为肺泡上皮祖细胞的骨髓来源细胞。
Development. 2001 Dec;128(24):5181-8. doi: 10.1242/dev.128.24.5181.
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Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality.特发性肺纤维化：组织病理学特征与死亡率之间的关系
Am J Respir Crit Care Med. 2001 Sep 15;164(6):1025-32. doi: 10.1164/ajrccm.164.6.2001056.
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Idiopathic pulmonary fibrosis.特发性肺纤维化
N Engl J Med. 2001 Aug 16;345(7):517-25. doi: 10.1056/NEJMra003200.
9
Peripheral blood fibrocytes: differentiation pathway and migration to wound sites.外周血纤维细胞：分化途径及向伤口部位的迁移
J Immunol. 2001 Jun 15;166(12):7556-62. doi: 10.4049/jimmunol.166.12.7556.
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Marrow stromal cells as stem cells for nonhematopoietic tissues.作为非造血组织干细胞的骨髓基质细胞。
Science. 1997 Apr 4;276(5309):71-4. doi: 10.1126/science.276.5309.71.