Liu Keh-Sen, Sheng Wang-Huei, Chen Yee-Chun, Chang Shan-Chwen, Hsieh Wei-Chuan
Section of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.
J Microbiol Immunol Infect. 2003 Dec;36(4):243-7.
To elucidate the causes of fever of unknown origin (FUO) in Taiwan, we retrospectively analyzed the characteristics of 78 adult patients meeting the classic criteria for fever of unknown origin who were treated at National Taiwan University Hospital from July 1999 through June 2002. Cause of FUO was due to infections in 42.3% of patients, neoplasms in 6.4%, noninfectious inflammatory diseases in 20.5%, and miscellaneous causes in 7.7%, whereas the cause was not established in 23.1% of patients despite every effort. Tuberculosis (14.1%) and acquired immunodeficiency syndrome (7.7%) were the most common causes of infection in patients with FUO, while intraabdominal abscess, infective endocarditis, and tumor were less frequently found. Noninfectious inflammatory diseases were still a very important cause of FUO and were difficult to diagnose. In conclusion, infection remains the most important cause of classic FUO in Taiwan, confirming the findings in previous series. The importance of tuberculosis and AIDS as frequent causes of FUO should be emphasized.
为阐明台湾地区不明原因发热（FUO）的病因，我们回顾性分析了1999年7月至2002年6月间在台湾大学附属医院接受治疗、符合不明原因发热经典标准的78例成年患者的特征。FUO的病因中，42.3%为感染，6.4%为肿瘤，20.5%为非感染性炎症性疾病，7.7%为其他杂项原因，另有23.1%的患者尽管竭尽全力仍未明确病因。结核病（14.1%）和获得性免疫缺陷综合征（7.7%）是FUO患者最常见的感染原因，而腹腔内脓肿、感染性心内膜炎和肿瘤则较少见。非感染性炎症性疾病仍是FUO的一个非常重要的病因且难以诊断。总之，感染仍是台湾地区经典FUO的最重要病因，证实了既往系列研究的结果。应强调结核病和艾滋病作为FUO常见病因的重要性。
