Department of Gastroenterology, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, China;
Chin J Cancer Res. 2012 Jun;24(2):157-60. doi: 10.1007/s11670-012-0157-0.
Fever of unknown origin (FUO) was originally defined as a body temperature greater than 38.3°C on several occasions longer than 3 weeks, with a diagnosis that remains unclear after 7 days of obligatory investigation. Only a few types of solid tumors have been associated with FUO. We described 2 patients who had recurrent fever but no other specific gastrointestinal symptoms where carcinoma of the colon was the only identifiable cause. In the first case, a mass arising from the sigmoid colon was found without any nodal metastasis, and the fever was resolved after three days of the surgical resection. In the second case, advanced adenocarcinoma was found in the ascending colon together with liver cirrhosis. Although it was not possible to surgically remove this tumor, prolonged fever in the patient was most likely due to the carcinoma. These cases indicate that clinicians should consider carcinoma of the colon in the differential diagnosis of patients with FUO.
不明原因发热（FUO）最初被定义为体温多次超过 38.3°C，持续时间超过 3 周，在经过 7 天的强制性检查后仍无法明确诊断。只有少数几种实体瘤与 FUO 相关。我们描述了 2 例复发性发热但无其他特定胃肠道症状的患者，其中结肠癌是唯一可识别的病因。在第一个病例中，从乙状结肠出现的肿块没有任何淋巴结转移，手术切除后三天发热消退。在第二个病例中，升结肠癌发现高级别腺癌合并肝硬化。尽管无法对该肿瘤进行手术切除，但患者的长期发热很可能是由于该癌所致。这些病例表明，临床医生在 FUO 患者的鉴别诊断中应考虑结肠癌。
