小儿HIV-1感染中的肿瘤坏死因子-α

Tumor necrosis factor-alpha in pediatric HIV-1 infection.

作者信息

Ellaurie M, Rubinstein A

机构信息

Special Immunology Service, Children's National Medical Center, Washington, District of Columbia.

出版信息

AIDS. 1992 Nov;6(11):1265-8. doi: 10.1097/00002030-199211000-00004.

DOI:10.1097/00002030-199211000-00004

PMID:1472332

Abstract

OBJECTIVE

To evaluate the diagnostic and prognostic value of serum tumor necrosis factor-alpha (TNF-alpha) levels in HIV-1-infected children.

DESIGN

Serum levels of TNF-alpha were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years.

METHODS

TNF-alpha levels were determined by enzyme immunoassay. The sensitivity of the assay was 10 pg/ml.

RESULTS

TNF-alpha levels (mean +/- s.d.) were significantly elevated in HIV-1-infected patients (285 +/- 390 pg/ml), compared with HIV-1-uninfected age-matched controls (22.7 +/- 4.9 pg/ml). Among HIV-1-infected children the highest levels of TNF-alpha were noted in those with Mycobacterium avium intracellulare (MAI) infection and those with interstitial lymphoid pneumonitis (LIP). In contrast, patients with Pneumocystis carinii pneumonia, progressive encephalopathy or cachexia did not have markedly elevated TNF-alpha levels.

CONCLUSIONS

Serum TNF-alpha is increased in symptomatic HIV-1-infected children, with higher levels in children with LIP or MAI. Serum TNF-alpha levels are not diagnostic for cachexia or progressive encephalopathy.

摘要

目的

评估血清肿瘤坏死因子-α（TNF-α）水平在HIV-1感染儿童中的诊断及预后价值。

设计

对57名年龄在7个月至8岁之间有症状的HIV-1感染儿童的血清TNF-α水平进行评估。

方法

采用酶免疫测定法测定TNF-α水平。该测定法的灵敏度为10 pg/ml。

结果

与年龄匹配的未感染HIV-1的对照组（22.7±4.9 pg/ml）相比，HIV-1感染患者的TNF-α水平（均值±标准差）显著升高（285±390 pg/ml）。在HIV-1感染儿童中，细胞内鸟分枝杆菌（MAI）感染患儿和间质性淋巴细胞肺炎（LIP）患儿的TNF-α水平最高。相比之下，卡氏肺孢子虫肺炎、进行性脑病或恶病质患者的TNF-α水平没有明显升高。