HIV感染儿童的鸟分枝杆菌胞内菌复合群感染
Mycobacterium avium intracellulare complex infection in HIV-infected children.
作者信息
Rutstein R M, Cobb P, McGowan K L, Pinto-Martin J, Starr S E
机构信息
Division of General Pediatrics, Children's Hospital of Philadelphia, PA 19104.
出版信息
AIDS. 1993 Apr;7(4):507-12. doi: 10.1097/00002030-199304000-00009.
OBJECTIVE
To describe the incidence of, and risk factors for, Mycobacterium avium intracellulare complex (MAC) infection in HIV-infected children.
SETTING
University-affiliated children's hospital.
DESIGN AND METHODS
The medical records of 70 HIV-infected infants and children were reviewed retrospectively.
RESULTS
Seven children (10% of the HIV-infected patients; 18% of those with AIDS) developed disseminated MAC (dMAC). An additional seven children had gastrointestinal colonization with MAC. Risk of dMAC was associated with increasing age, decreasing CD4 cell count, and (possibly) long-term steroid therapy.
CONCLUSIONS
HIV-infected children are at risk of developing dMAC. Children older than 60 months and those with a CD4 cell count < 100 x 10(6)/l are most at risk.
目的
描述HIV感染儿童鸟分枝杆菌胞内复合物（MAC）感染的发生率及危险因素。
地点
大学附属医院儿童医院。
设计与方法
回顾性分析70例HIV感染婴幼儿及儿童的病历。
结果
7例儿童（占HIV感染患者的10%；艾滋病患者的18%）发生播散性MAC（dMAC）。另有7例儿童胃肠道有MAC定植。dMAC的风险与年龄增长、CD4细胞计数降低以及（可能）长期使用类固醇治疗有关。
结论
HIV感染儿童有发生dMAC的风险。60个月以上儿童及CD4细胞计数<100×10⁶/L的儿童风险最高。
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