Joseph Anne M, Nelson David B, Nugent Sean M, Willenbring Mark L
Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, and the University of Minnesota, Minneapolis, MN, USA.
J Addict Dis. 2003;22(4):87-107. doi: 10.1300/j069v22n04_08.
Tobacco dependence is prevalent among alcohol dependent patients, and causes increased morbidity and mortality. Concurrent treatment for these disorders may be advantageous, but there are concerns about adverse effects on alcohol treatment outcomes. The Timing of Alcohol and Smoking Cessation (TASC) Study is a randomized controlled clinical trial to compare the effectiveness of smoking cessation treatment offered concurrently or six months following intensive rehabilitation for alcohol dependence. This paper describes the study design and baseline characteristics of the study population. Participants were current smokers in intensive alcohol dependence treatment, with willingness to consider quitting smoking. Smoking intervention offered behavioral and pharmacological treatment. One thousand nine hundred forty-three patients were screened for enrollment; 499 were eligible and participated (26%). We describe demographic characteristics, smoking behavior and attitudes among participants and nonparticipants toward smoking cessation and drinking. We conclude that there is considerable interest in smoking cessation in alcohol dependent treatment populations, and recruitment to research studies is feasible.
烟草依赖在酒精依赖患者中很普遍，会导致发病率和死亡率上升。对这些疾病进行联合治疗可能有益，但人们担心这会对酒精治疗效果产生不良影响。酒精与戒烟时机（TASC）研究是一项随机对照临床试验，旨在比较在酒精依赖强化康复治疗期间同时提供戒烟治疗或在治疗六个月后提供戒烟治疗的效果。本文描述了该研究的设计以及研究人群的基线特征。参与者为正在接受酒精依赖强化治疗的当前吸烟者，且愿意考虑戒烟。吸烟干预提供行为和药物治疗。对1943名患者进行了入组筛查；499名符合条件并参与研究（26%）。我们描述了参与者和非参与者的人口统计学特征、吸烟行为以及对戒烟和戒酒的态度。我们得出结论，酒精依赖治疗人群对戒烟有相当大的兴趣，招募患者参与研究是可行的。
