Keith John M, Jacobsen Eric N
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Org Lett. 2004 Jan 22;6(2):153-5. doi: 10.1021/ol035844c.
[reaction: see text] The asymmetric addition of HCN to hydrazones is catalyzed in high yield and good-to-excellent enantioselectivity by the easily prepared (PhPYBOX)ErCl3 complex. This constitutes the first example of asymmetric catalytic hydrocyanation of hydrazones.
[反应：见正文] 易于制备的(PhPYBOX)ErCl3配合物能高效催化腙的HCN不对称加成反应，对映选择性良好至优异。这是腙不对称催化氢氰化反应的首例。
