Liu Pei Nian, Gu Pei Ming, Wang Fei, Tu Yong Qiang
Department of Chemistry and State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, PR China.
Org Lett. 2004 Jan 22;6(2):169-72. doi: 10.1021/ol036065z.
[reaction: see text] Chiral Ru-TsDPEN [N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-derived catalysts were first successfully immobilized onto amorphous silica gel and mesoporous silicas of MCM-41 and SBA-15 by an easily accessible approach. The catalyst immobilized on silica gel demonstrated remarkably high catalytic activities and excellent enantioselectivities (up to >99% ee) for the heterogeneous asymmetric transfer hydrogenation of various ketones. Particularly, the catalyst could be readily recovered and reused in multiple consecutive catalytic runs (up to 10 uses) with the completely maintained enantioselectivity.
[反应：见正文] 手性钌 - TsDPEN [N -（对甲苯磺酰基）-1,2 - 二苯基乙二胺]衍生的催化剂首次通过一种易于实现的方法成功固定在无定形硅胶以及MCM - 41和SBA - 15的介孔二氧化硅上。固定在硅胶上的催化剂对各种酮的多相不对称转移氢化表现出极高的催化活性和优异的对映选择性（高达>99% ee）。特别地，该催化剂可以很容易地回收，并在多次连续催化运行（高达10次使用）中重复使用，且对映选择性完全保持。
