用于在无碱条件下对芳香酮进行不对称转移氢化的高效铱催化剂。
Highly efficient iridium catalyst for asymmetric transfer hydrogenation of aromatic ketones under base-free conditions.
作者信息
Dong Zhen-Rong, Li Yan-Yun, Chen Jian-Shan, Li Bao-Zhu, Xing Yan, Gao Jing-Xing
机构信息
State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China.
出版信息
Org Lett. 2005 Mar 17;7(6):1043-5. doi: 10.1021/ol047412n.
[reaction: see text] Catalytic systems generated in situ from the chiral PNNP ligands with iridium or rhodium hydride complexes exhibited excellent catalytic activity and good enantioselectivity in the asymmetric transfer hydrogenation of aromatic ketones without added base. The best result was obtained in the IrH(CO)(PPh(3))(3)-ligand 2 catalytic system with up to 99% yield and 97% ee.
[反应：见正文] 由手性PNNP配体与氢化铱或铑配合物原位生成的催化体系，在不添加碱的情况下，对芳香酮的不对称转移氢化反应表现出优异的催化活性和良好的对映选择性。在IrH(CO)(PPh(3))(3)-配体2催化体系中获得了最佳结果，产率高达99%，对映体过量值为97%。
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