Terasaki K, Kanekura T, Saruwatari H, Kanzaki T
Department of Dermatology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Clin Exp Dermatol. 2004 Jan;29(1):49-51. doi: 10.1111/j.1365-2230.2004.01449.x.
We report a case of classical juvenile pityriasis rubra pilaris (CJPRP) in a 15-year-old boy with Down syndrome. The rash was extensive, severe, accompanied by intense itching and responded to low-dose etretinate. Xerosis and cheilitis were also present, suggesting that keratinization defects associated with Down syndrome may be involved in the pathogenesis of CJPRP. PRP is a rare dermatological disorder and to the best of our knowledge, this is the first reported case of CJPRP in a patient with Down syndrome.
我们报告了一例15岁患有唐氏综合征男孩的经典型青少年毛发红糠疹（CJPRP）病例。皮疹广泛、严重，伴有剧烈瘙痒，对低剂量阿维A酯有反应。还存在皮肤干燥和唇炎，提示与唐氏综合征相关的角化缺陷可能参与了CJPRP的发病机制。毛发红糠疹是一种罕见的皮肤病，据我们所知，这是首例唐氏综合征患者并发CJPRP的报道。
