内皮素与肝脏疾病中的血管功能
Endothelin and vascular function in liver disease.
作者信息
Moore K
机构信息
Centre for Hepatology, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK.
出版信息
Gut. 2004 Feb;53(2):159-61. doi: 10.1136/gut.2003.024703.
Abstract
The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogenesis of acute renal failure, including hepatorenal syndrome, has also been speculated.
摘要
内皮素是一组由三种相关肽组成的物质，具有两种受体亚型，即ET(A)和ET(B)。在发现内皮素-1是一种强效血管收缩剂之后，人们对内皮素在肝脏疾病血管功能中的作用产生了浓厚兴趣。关于内皮素在急性肾衰竭（包括肝肾综合征）发病机制中的作用也有诸多推测。
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本文引用的文献
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Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation.晚期肝硬化患者对外源性内皮素-1的血管反应改变，肝移植成功后正常血管收缩反应得以恢复的证据。
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