Goodnough Lawrence T
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.
Crit Care Med. 2003 Dec;31(12 Suppl):S678-86. doi: 10.1097/01.CCM.0000100124.50579.D9.
To review the current status of risks of blood transfusion.
DATA SOURCES, EXTRACTIONS, AND SYNTHESIS: English-speaking literature, literature search using key works, human data, and follow-up with key bibliographic citations.
Substantial advances have been achieved in blood safety during the last 20 yrs, particularly for transfusion-transmitted viral infections. Currently, the most serious known risks from blood transfusion are administrative error (leading to ABO-incompatible blood transfusion), transfusion-related acute lung injury, and bacterial contamination in platelet products. Emerging pathogens, such as West Nile virus infection emphasize the need for implementation of proactive strategies, such as pathogen inactivation technologies, as well as reactive strategies, such as nucleic acid testing, to ensure continued advances in blood safety.
回顾输血风险的现状。
数据来源、提取与综合：英文文献，使用关键词进行文献检索，人体数据，并追踪关键参考文献。
在过去20年中，血液安全取得了重大进展，尤其是在输血传播病毒感染方面。目前，已知输血最严重的风险是管理失误（导致ABO血型不相容输血）、输血相关急性肺损伤以及血小板制品中的细菌污染。西尼罗河病毒感染等新出现的病原体强调了实施诸如病原体灭活技术等主动策略以及诸如核酸检测等被动策略的必要性，以确保血液安全持续取得进展。
