MMWR Morb Mortal Wkly Rep. 2004 Jan 16;53(1):8-11.
Influenza activity started earlier than usual in the United States this season, with widespread influenza activity reported in 10 states by November 22, 2003. The predominant influenza viruses (A/Fujian/411/2002 [H3N2]-like viruses) circulating this season differ antigenically from the 2003-04 influenza A (H3N2) vaccine strain. A retrospective cohort study was conducted among workers at a Colorado hospital to provide preliminary data on the effectiveness of trivalent inactivated influenza vaccine (TIV) against influenza-like illness (ILI). This report summarizes the results of that study, which indicated that TIV had no or low effectiveness against ILI. However, additional studies are needed to evaluate the effectiveness of the 2003-04 vaccine against laboratory-confirmed influenza and influenza-related complications, including hospitalization and death. Influenza vaccine continues to be recommended, particularly for persons at increased risk for influenza-related complications, their household contacts, and health-care personnel.
本季美国流感活动比往年开始得更早，截至2003年11月22日，已有10个州报告出现广泛的流感活动。本季流行的主要流感病毒（A/福建/411/2002 [H3N2] 样病毒）在抗原性上与2003-2004年流感A（H3N2）疫苗株不同。在科罗拉多州一家医院的工作人员中进行了一项回顾性队列研究，以提供关于三价灭活流感疫苗（TIV）预防流感样疾病（ILI）有效性的初步数据。本报告总结了该研究结果，结果表明TIV对ILI无效或有效性较低。然而，需要进行更多研究来评估2003-2004年疫苗对实验室确诊流感及流感相关并发症（包括住院和死亡）的有效性。仍然建议接种流感疫苗，特别是对于流感相关并发症风险增加的人群、其家庭接触者以及医护人员。
