Baldo V, Bertoncello C, Cocchio S, Fonzo M, Pillon P, Buja A, Baldovin T
Department of Molecular Medicine, Public Health Section, University of Padua, Italy.
J Prev Med Hyg. 2016;57(1):E19-22.
In June 2009, the World Health Organization (WHO) issued a pandemic alert concerning the spread of an influenza A (H1N1) virus that showed distinctive genetic characteristics vis-à-vis both seasonal influenza strains and vaccine strains. The main mutation occurred in the gene coding for hemagglutinin (HA). Mathematical models were developed to calculate the transmissibility of the virus; the results indicated a significant overlap with the transmissibility of previous pandemic strains and seasonal strains. The remarkable feature of A/(H1N1)pdm09, compared with seasonal strains, is its high fatality rate and its higher incidence among younger people. Data provided by the WHO on the number of deaths caused by A/(H1N1)pdm09 only include laboratory-confirmed cases. Some authors suggest that these data could underestimate the magnitude of the event, as laboratory confirmation is not obtained in all cases. It is important to bear in mind that the A/(H1N1)pdm09 virus is still circulating in the population. It is therefore essential to maintain its epidemiological and virological surveillance.
2009年6月，世界卫生组织（WHO）发布了一项关于甲型H1N1流感病毒传播的大流行警报，该病毒在基因特征上与季节性流感毒株和疫苗毒株均有明显差异。主要突变发生在编码血凝素（HA）的基因中。人们建立了数学模型来计算该病毒的传播能力；结果表明，其与以往大流行毒株和季节性毒株的传播能力有显著重叠。与季节性毒株相比，甲型H1N1流感大流行病毒（A/(H1N1)pdm09）的显著特征是其高致死率以及在年轻人中的较高发病率。WHO提供的关于A/(H1N1)pdm09导致的死亡人数的数据仅包括实验室确诊病例。一些作者认为，这些数据可能低估了该事件的规模，因为并非所有病例都获得了实验室确诊。必须牢记，A/(H1N1)pdm09病毒仍在人群中传播。因此，维持对其的流行病学和病毒学监测至关重要。
