Bauvois Brigitte
Brigitte Bauvois, Unité 507 INSERM, Hôpital Necker, Bâtiment Lavoisier, 161 rue de Sèvres, 75015 Paris, France.
Oncogene. 2004 Jan 15;23(2):317-29. doi: 10.1038/sj.onc.1207124.
Transmembrane proteases (TPs) are proteins anchored in the plasma membrane with their catalytic site exposed to the external surface of the membrane. TPs are widely expressed, and their dysregulated expression is associated with cancer, infection, inflammation, autoimmune and cardiovascular diseases, all diseases where angiogenesis is part of the pathology. TPs participate in extracellular proteolysis (degradation of extracellular matrix components, regulation of chemokine activity, release of membrane-anchored cytokines, cytokine receptors and adhesion molecules) and influence cell functions (growth, secretion of angiogenic molecules, motility). Recent attention has been focused on the ADAM-17 (a disintegrin and metalloprotease)/TACE/CD156q, the MT1-MMP (membrane-type-1 matrix metallo proteinase)/MMP-14, and the ectopeptidases aminopeptidase N (APN/CD13), dipeptidyl peptidase IV (DPPIV/CD26) and angiotensin-converting enzyme (ACE/CD143), that appear to have a critical role in angiogenesis. This article summarizes current knowledge on these TPs, and reviews recent investigations that document their participation during angiogenic-related events. Through their multiple roles, TPs may thereby provide critical links in angiogenesis.
跨膜蛋白酶（TPs）是锚定在质膜上的蛋白质，其催化位点暴露于膜的外表面。TPs广泛表达，其表达失调与癌症、感染、炎症、自身免疫性疾病和心血管疾病相关，这些疾病的病理过程均涉及血管生成。TPs参与细胞外蛋白水解（细胞外基质成分的降解、趋化因子活性的调节、膜锚定细胞因子、细胞因子受体和黏附分子的释放）并影响细胞功能（生长、血管生成分子的分泌、运动性）。近期的研究重点集中在ADAM-17（一种去整合素和金属蛋白酶）/肿瘤坏死因子α转换酶/TACE/CD156q、MT1-MMP（膜型-1基质金属蛋白酶）/MMP-14以及外肽酶氨肽酶N（APN/CD13）、二肽基肽酶IV（DPPIV/CD26）和血管紧张素转换酶（ACE/CD143），这些酶似乎在血管生成中起关键作用。本文总结了目前关于这些TPs的知识，并综述了近期记录它们在血管生成相关事件中作用的研究。通过其多种作用，TPs可能在血管生成中提供关键联系。
